Study: Cannabinoids May Be Beneficial Treament For Parkinson’s Disease

According to a study that was published online by the National Institute of Health, certain marijuana-derived compounds (mainly THC) could be effective treatments for Parkinson’s disease due to the fact that they are neuroprotective.

The study’s researchers, from the Plymouth University Peninsula Schools of Medicine and Dentistry, examined cell-culture models of Parkinson’s disease, and by doing so discovered that, “THC resulted in significant inhibition of MPP+ induced oxidative stress.” To which they concluded that, “THC induces PPARγ dependent mitochondrial biogenesis, a mechanism that may be beneficial for the treatment of PD.”

“Cannabinoids such as Δ9-tetrahydrocannabinol (Δ9-THC) are neuroprotective in animal and cell culture models of Parkinson’s disease (PD). In a PD cell culture model we recently demonstrated that Δ9-THC is neuroprotective through activation of the nuclear receptor peroxisomal proliferator-activated receptor γ (PPARγ),” according to the study’s introduction.

The study goes on to show that through the co-administration of THC and pioglitazone added with “the minimum concentration of the specific PPARγ antagonist T0070907,” it was possible to “block the protective effect of each compound respectively for 48 hours.”

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